Education remains one of the largest challenges to our product manufacturers and brands. At the time of this writing, the CBD industry is highly unregulated, and therefore consumer confidence remains low. Some factors that affect the industry at large are:
- Many products do not offer Certificate of Analysis (COA) showing how much actual CBD is in the finished products.
- Many products are not able to establish a minimum effective dose (MED), which is compounded by using old delivery methods such as oil-based tinctures and macro suspensions.
- Lack of consistency between batches.
- Products have been tested, and some of them contain little to zero CBD.
- Lack of education the differences between grades of active CBD (full spectrum, broad spectrum, Isolate).
- A need to educate on the legality of CBD, additionally how drug testing intersects the CBD movement.
Bio-availability is defined as “The proportion of a drug or other substance which enters the circulation when introduced into the body and is able to have an active effect.” CBD is classified by the pharmaceutical class system as a Type 2 drug which exhibits poor aqueous solubility and high permeability.
One of the main disadvantages of such “drugs” is they need careful formulation to avoid being degraded, metabolized, and cleared by the digestive system. It first passes metabolism (liver) before being absorbed, which is a problem. 70% of drugs on the market today fall into this classification of exhibiting poor aqueous solubility.
The mainstream CBD industry focuses on oil based delivery formulations, which are grossly archaic in the pharmaceutical and medical field. Many companies and consumers have never heard of bio-availability, and are unaware that up to 70% of the CBD they are taking in is being cleared by the body before ever making it into the bloodstream. Infused by Epic uses cutting edge technology borrowed in parts from food and Pharma sectors to deliver the best industry practices for enhanced drug delivery. The future of the CBD and wellness industry will be built on the platform of enhanced therapeutic delivery systems.
WHAT DOES NANO MEAN AND IS IT IMPORTANT?
Nano, from the words’s roots, simply means “small”. The particles are much smaller than particles delivered through a Micro, or Macro suspension. To put things into perspective, a human red blood cell is approximately 5,000 nanometers.
ELEVARx particles are under 50 nanometers, a 100x smaller than a blood cell. When the same amount of CBD is broken down to such a small particle size, the surface area increases exponentially. The greater the surface area, the more potential for bonding at the ECS receptor sites occurs.
Nano emulsification is one method to make particles small, and remain small while suspended in an aqueous medium. The surface active modifiers used in the formulation must be non-toxic, and be able to achieve high shelf stability without separating, especially when dissolved in a beverage or infused in food.
Nano emulsions offer customizable concentrates with active drug loading to meet the end products’ needs.
An example of this would be ELEVARx’s standard emulsion which is able to load 10mg of Nano CBD into 1 milliliter (ml) of water. This can be diluted into a beverage easily and uses a minimum of extra ingredients.
ELEVARx proudly uses only clean label natural ingredients. Many companies use synthetic ingredients to achieve homogeneity.
We don’t use artificial colors which have been proven to be harmful such as red 40, blue 1, or blue 2. We use food grade GRAS ingredients to coat the CBD molecules in our water soluble suspensions.
We are also vegan, allergy free, and use organic ingredients. This translates to compatibility with many sensitives which exist in today’s marketplace, along with high consumer confidence.
PRODUCT CHARACTERISTICS: Color, Taste and Stability
Our products will have a clear to translucent appearance. This measurement is known as the polydisperse index (PDI) and is a measurement of optical clarity.
Our nanoemulsions rank under 0.2, which is ultra clear. The smaller a particle is, the less it will scatter light, which produces turbidity or cloudiness. When you incorporate ELEVARx products into your formulations, there will be no optical change seen.
Just as the effects of our product are amplified, so is the taste. By working with source materials such as full spectrum and broad spectrum distillates, the entourage of terpenes and phytocannabinoids can help create a more robust flavor profile.
Expect a linear correlation between the effects and the taste when using Nano based products is more bitter than traditional oils. You can taste the potency. But dissolved in a flavored drink or a large ratio liquid to Nano, it will dilute the bitterness.
Our products are shelf stable for 1 year and will remain as stable as the formulation they are infused into. We recommend avoiding exposure of any cannabinoids to UV light as it can degrade the CBD molecules. This is true with any active ingredients, Nano or oil based.
FASTER ONSET & HIGHER EFFICACY
The formulations used by ELEVARx offer advantages for product formulators, and ultimately consumers, to deliver a higher portion of consumed active ingredients directly into the bloodstream and avoiding digestive degradation.
The consumer will be getting near 100% of the active CBD they are paying for. A direct effect of bioavailability is the enhanced permeation and retention effect (EPR).
This means that the consumer can start feeling therapeutic effects much faster than a standard oil formulation. All in all, more of the active CBD is transferred to the bloodstream and achieved by a faster onset.
NANO COSTS MORE PER MG THAN OIL BASED FORMULAS – But with Nano you actually need less mg to receive the same amount which in the end, makes Nano products less expensive.
One of the most noticeable differences from the formulator’s standpoint is the price increase using a Nano-formulation VS using straight CBD oil or isolate. The ingredients’ costs can be 3x to 5x as much as using an inferior oil based product.
The main reason for this is tremendous R&D costs, as well as excipient ingredients of the highest purity and expensive machinery used to refine and further purify the active substances in the new Nano formulations
The decision to switch to Nano may seem expensive, but the benefits far outweigh the initial upfront costs. Nearing 100% bio-availability, faster onset, and the ability to work with water-based formulations are only a few of the obvious benefits.
EASE OF FORMULATION
Product formulators can now use ELEVARx to achieve a few of the following industrial advantages:
- Direct infusibility into water based formulations (tinctures, beverages, transdermals, cosmeceuticals, IV, etc. Water soluble powder into dry water soluble formulations)
- Complete homogeneity – no separation within the water based product (gummies, creams beverages, chocolates etc.)
- Accuracy of dosage infusion
- Products with a faster therapeutic onset
- Products with greater bioavailability
- High shelf stability
- Versatility in development of new product categories.
WHAT ABOUT SOURCE MATERIALS?
ELEVARx proudly uses only the cleanest third-party tested CBD products in our emulsified formulations. We also are proud to offer flexibility for brands dedicated to preserving the quality of their established supply chains and sources.
In the latter case, Infused by Epic can offer particle coating services. In this case, we would take the source material either in isolate or distillate form, with a passing COA, and convert the source material into a “Nanotized” suspension that be reintroduced into the end formulation.
Will ELEVARx products show a higher percentage of CBD when tested by a laboratory?
No, the amount of active CBD/g will not increase as a result of nano emulsification, however, the surface area will have increased considerably. The laboratory testing your formulation should be aware you’re using a colloidal water soluble suspension, as their procedures may differ from an oil solvency procedure, which is commonplace.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Please consult a physician before using any products. Do not use while pregnant.